The Histology and Genetic Modification (HGeM) Core Facility at the University of Oregon (UO) provides a technology resource to the local and regional research community to support the generation, analysis and maintenance of genetically modified organisms.  It was originally established in 2004.

The facility offers expertise in a wide variety of technical procedures:

  • cryo and paraffin sections
  • histological stains
  • pronuclear injections
  • blastocyst injections
  • tissue culture for the manipulation of mouse Embryonic Stem (ES) cells
  • cryopreservation of embryos
  • in vitro fertilization
  • rederivation of mouse strains
  • repository of commonly used strains
  • customized project and colony management
  • genotyping services

HGeM also operates a transgenic barrier holding facility. The facility is fully equipped for microinjections, microsurgery, cryopreservation, gene targeting and tissue culture as well as standard molecular techniques.

HGeM staff provide expertise, materials and training on a fee-for-service basis. Principal investigators who request services are required to provide a rationale for each project and to obtain IACUC approval.

Acknowledgement & Authorship

The Core Facilities at the University of Oregon are here to support your research. In order to ensure that the appropriate recognition is attributed to the facilities, we request that any scientific publications or presentations involving these transgenic animals acknowledge the services of the University of Oregon Histology and Genetic Modification Core Facility (HGeM).



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